A supporting frame with locating function mainly includes a supporting portion and a plurality of connecting portions. The supporting portion is provided at a central area with a plurality of hollow spaces, and is connected at an upper side to a fan and at a lower side to a radiator. The supporting portion is provided on a rim area with fixing holes, via which fastening elements are extended to connect the supporting portion to the radiator. Each of the connecting portions includes an axially extended connecting hole, in which a locating mechanism is received. The connecting portion is connected at an upper side to the supporting portion, and at a lower side to a main board via screwing and elastic elements of the locating mechanism. With the supporting frame, the fan and the radiator can be quickly assembled to the main board.