An interstitial fluid (ISF) extraction device includes a penetration
member configured for penetrating a target site of a user's skin layer
and, subsequently, residing in the user's skin layer and extracting an
ISF sample therefrom and at least three concentrically-arranged pressure
rings, each adapted for applying pressure to the user's skin layer in the
vicinity of the target site while the penetration member is residing in
the user's skin layer. In addition, the ISF extraction device is
configured such that (i) the pressure rings apply pressure in an
oscillating manner with asymmetric deployment and retraction cycles and
(ii) only one of the at least three concentrically-arranged pressure
rings is deployed at a time, thereby mitigating an ISF glucose lag of the
ISF sample extracted by the penetration member.