An electrotransport agent delivery device (10) for delivering a
therapeutic agent through intact skin, and a method of operating same, is
provided. The device applies a pulsing electrotransport current wherein
current pulses have a magnitude above a critical level (I.sub.c) at which
the skin is transformed into a higher electrotransport delivery
efficiency (E) state. Most preferably the length of the applied current
pulses is at least 5 msec and preferably at least 10 msec.