A two-dimensional (2D) chemical shift correlated MR spectroscopic (COSY)
sequence integrated into a new volume localization technique
(90.degree.-180.degree.-90.degree.) for whole body MR Spectroscopy. Using
the product operator formalism, a theoretical calculation of the volume
localization as well as the coherence transfer efficiencies in 2D MRS is
presented. A combination of different MRI transmit/receive rf coils is
used. The cross peak intensities excited by the proposed 2D sequence are
asymmetric with respect to the diagonal peaks. Localized COSY spectra of
cerebral frontal and occipital gray/white matter regions in fifteen
healthy controls are presented.