The present application describes monocyclic and bicyclic lactams and
derivatives thereof of Formulae Ia e: ##STR00001## wherein one of one of
T.sup.1 and T.sup.2 is carbonyl, thiocarbonyl, or sulfonyl or
pharmaceutically acceptable salt forms thereof. Compounds of the present
invention are useful as inhibitors of trypsin-like serine proteases,
specifically factor Xa.