Pharmaceutical compositions are provided comprising one or more orally
deliverable dose units, each comprising a selective cyclooxygenase-2
inhibitory drug of low water solubility in a therapeutically effective
amount, wherein the drug is present in the form of solid particle, about
25% to 100% by weight of which are smaller than 1 .mu.m. The compositions
are useful in treatment or prophylaxis of cyclooxygenase-2 mediated
conditions and disorders and have particular advantages where rapid onset
of therapeutic effect is desired.