Complications of various diseases have ascertainable direct costs and indirect costs. A method of projecting direct and indirect cost savings which may be realized from targeted interventions for achieving desired clinical outcomes which may result in the avoidance or mitigation of the complication is provided. Further, a comprehensive patient care management program is provided whereby the targeted intervention strategy of the present invention provides a list of behavioral influencers which assist in achieving desired clinical outcomes. From the achievement of the desired clinical outcomes direct and indirect cost savings from the avoidance or mitigation of a complication provides a projected overall cost savings which may be realized for an employer sponsored health plan.