An audio generation system includes MIDI track components that generate event instructions for MIDI audio data received from a MIDI audio data source, and includes audio wave track components that generate playback instructions for audio wave data maintained in an audio wave data source. A segment component plays one or more of the MIDI track components to generate the event instructions, and plays one or more of the audio wave track components to generate the playback instructions. An audio processing component, such as a synthesizer component, receives the event instructions and the playback instructions, and generates an audio rendition corresponding to the MIDI audio data and/or the audio wave data.