An anti-rotation guide for preventing rotation of a roller follower valve lifter in an internal combustion engine. The guide has an outer surface for engaging an engine bore and an inner surface for slidably receiving the lifter. One end of the guide includes an anti-rotation feature for cooperating with a mating feature on the lifter, preferably flats although other configurations are contemplated within the scope of the invention. The anti-rotation feature may take any of a plurality of shapes, including but not limited to an arm and tang, a flap, and an orifice flat. The guide is installed from an opening in the engine bore proximate a camshaft disposed in the engine block. The cooperating features prevent axial rotation of a lifter within the sleeve but do not inhibit axial or reciprocal motion of the lifter.