Compounds having activity against production of an inflammatory cytokine of formula (I)': ##STR00001## A' is pyrrole; R.sup.1' is phenyl or naphthyl; R.sup.2' is pyridyl or pyrimidinyl; R.sup.3' is (IIa)', (IIb)' or (IIc)': ##STR00002## m' is 1; E' is nitrogen; D' is >C(R.sup.5')--, R.sup.5' is hydrogen, Substituent .alpha.' or Substituent .beta.'; B' is nitrogen-containing 5-membered heterocyclic; R.sup.4' is 1 to 3 substituents from Substituent .alpha.', Substituent .beta.' and Substituent .gamma.'; R.sup.1' and R.sup.3' are bonded to two atoms of the pyrrole adjacent to the pyrrole atom bonded to R.sup.2'; Substituent .alpha.' is hydroxyl, nitro, cyano, halogen, alkoxy, halogeno alkoxy, alkylthio, halogeno alkylthio or --NR.sup.a'R.sup.b'; R.sup.a' and R.sup.b' are hydrogen, alkyl, alkenyl, alkynyl, aralkyl or alkylsulfonyl, or R.sup.a' and R.sup.b' with the nitrogen atom form a heterocyclyl; Substituent .beta.' is alkyl, alkenyl, alkynyl, aralkyl or cycloalkyl; Substituent .gamma.' is oxo, hydroxyimino, alkoxyimino, alkylene, alkylenedioxy, alkylsulfinyl, alkylsulfonyl, aryl, aryloxy, alkylidenyl or aralkylidenyl.