The present invention discloses a prosthetic bone implant made of a hardened calcium phosphate cement having an apatitic phase as a major phase, which includes a dense cortical portion bearing the majority of load and a porous cancellous portion allowing a rapid blood/body fluid penetration and tissue ingrowth.

 
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> Physiological tissue repair and functional organ regeneration by cultivation of regenerative stem cells in vivo and in situ

> Use of a polysaccharide excreted by the Vibrio diabolicus species in bone repair

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