The present invention provides three-dimensional structural information from the hyperthermophilic bacterium Aquifex aeolicus which is a histone deacetylase-like protein (HDLP). HDLP shares 35.2% amino acid sequence identity with human histone deacetylase (HDAC1). The present invention further provides three-dimensional structural information of HDLP bound by inhibitor molecules. The three-dimensional structural information of the present invention is useful to design, isolate and screen deacetylase inhibitor compounds capable of inhibiting HDLP, HDAC family members and HDLP-related molecules. The invention also relates to nucleic acids encoding a mutant HDLP which facilitates the determination of the three-dimensional structure of HDLP in the presence of a zinc atom.

 
Web www.patentalert.com

< Method for classifying and localizing heart arrhythmias

< System for monitoring regulation of pharmaceuticals from data structure of medical and labortory records

> Arrangement for and method of expediting transactions based on a customer's proximity to the transactions

> Layer configuration comprising an electron-blocking element

~ 00295