A cotton cultivar, designated DP 543 BGII/RR, is disclosed. The invention relates to the seeds of cotton cultivar DP 543 BGII/RR, to the plants of cotton DP 543 BGII/RR and to methods for producing a cotton plant produced by crossing the cultivar DP 543 BGII/RR with itself or another cotton variety. The invention further relates to hybrid cotton seeds and plants produced by crossing the cultivar DP 543 BGII/RR with another cotton cultivar.

 
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