Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor,
e.g., a morphinan such as dextromethorphan or dextrorphan, or that block
a major intracellular consequence of NMDA-receptor activation, e.g., a
ganglioside such as GM.sub.1 or GT.sub.1b, a phenothiazine such as
trifluoperazine or a naphthalenesulfonamide such as
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, inhibit the
development of tolerance to and/or dependence on addictive drugs, e.g.,
narcotic analgesics such as morphine, codeine, etc.