The present invention provides compositions and methods of inhibiting
fibrin(ogen) clot formation by utilizing decorin proteoglycan as an
anticoagulating and antithrombotic agent. The decorin proteoglycan
comprises a decorin core protein or a fragment thereof covalently linked
to a galactosaminoglycan polysaccharide. The decorin core protein acts as
an anticoagulant and as a carrier for the delivery of an antithrombotic
galactosaminoglycan to fibrinogen. Fibrin clotting is inhibited by the
decorin proteoglycan in a concentration-dependent fashion.