The present invention relates to newly identified human ADHs belonging to
the superfamily of mammalian alcohol dehydrogenases. The invention also
relates to polynucleotides encoding the ADHs. The invention further
relates to methods using the ADH polypeptides and polynucleotides as a
target for diagnosis and treatment in ADH-mediated or -related disorders.
The invention further relates to drug-screening methods using the ADH
polypeptides and polynucleotides to identify agonists and antagonists for
diagnosis and treatment. The invention further encompasses agonists and
antagonists based on the ADH polypeptides and polynucleotides. The
invention further relates to procedures for producing the ADH
polypeptides and polynucleotides.