The present invention relates to replication protein A (RPA) transcriptional factors. There is provided a nucleotide sequence encoding a replication protein A transcriptional activator 1 (RTB1) and a protein encoded by such a nucleotide sequence. RBT1 has a high activity and is highly transactivated in cancer cells. The sequence may be used to treat neoplastic disorders and in gene therapy.

 
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> Poly ADP-ribose polymerase gene and it uses

> Cloning and characterization of the broad-spectrum resistance gene Pi2
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