A computer controlled system, method, and corresponding computer data product for determining a range of image decimation values for use in processing of images within a machine vision system. The system and method generates a high resolution reference image, generates a set of decimated reference images from the high resolution reference image, generates a set of interpolated reference images having a spatial image resolution identical to the high resolution reference image from the set of decimated images, cross-correlates the set of interpolated reference images with the high resolution reference image to generate a set of cross-correlation values, and selects a subset of the set of decimated reference images corresponding to interpolated references images that generated a cross correlation value greater than a predetermined threshold value.