Method and system for lesion detection is disclosed. A lesion is detected from each data set in the spatial domain based on an organ intensity subtracted (OIST) image. In the temporal domain, the lesion is detected based on a maximum frequency-magnitude difference (MFMD) map across a plurality of data sets. The detection result from the spatial domain and the detection result from the temporal domain are integrated to produce an integrated lesion detection result.

 
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