A system for applying a makeup and/or beauty care formulation may include a container and a makeup and/or beauty care formulation contained in the container. The makeup and/or beauty care formulation may be thermally stable and may have a thermal profile having a melting peak with a width at mid-height, L.sub.f, of less than or equal to 20.degree. C. The system may further include an applicator device for applying the makeup and/or beauty care formulation, and a heating member configured to raise the temperature of the formulation, before, during, or after application of the formulation, above the formulation's melting point.

 
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> Oligonucleotides and use of oligonucleotides modulating the expression of enzymes involved in the synthesis of melanic pigments, as depigmentation agents

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