The invention provides novel compounds of the Formula (I) that stimulate
rates of glucose oxidation in myocardial cells. The invention also
relates to pharmaceutical compositions comprising compounds capable of
stimulation of glucose oxidation, methods for increasing glucose
oxidation rates in myocardial cells, and methods of treatment of
myocardial ischemia ##STR00001## wherein W is C.sub.1 C.sub.6 alkyl,
halogen, or aryl; Cyc is C.sub.3 or C.sub.4 cycloalkyl; p is 0 3 for Cyc
being C.sub.4 cycloalkyl and p=0 2 for Cyc being C.sub.3 cycloalkyl; Y is
O, S, or NR, where R.dbd.H, alkyl or aryl; X is O, S, NR, or
CR.sup.3R.sup.4; Z is H, alkyl, cycloalkyl, aryl or (cyclo)alkylcarbonyl;
R.sup.1 is H, alkyl, aryl or O; R.sup.2 is H, alkyl or aryl; R.sup.3 and
R.sup.4 are, independently, H, alkyl or aryl; and n is an integer from 1
to 10; or a pharmaceutically acceptable salt, ester or prodrug thereof.