The invention provides novel compounds of the Formula (I) that stimulate rates of glucose oxidation in myocardial cells. The invention also relates to pharmaceutical compositions comprising compounds capable of stimulation of glucose oxidation, methods for increasing glucose oxidation rates in myocardial cells, and methods of treatment of myocardial ischemia ##STR00001## wherein W is C.sub.1 C.sub.6 alkyl, halogen, or aryl; Cyc is C.sub.3 or C.sub.4 cycloalkyl; p is 0 3 for Cyc being C.sub.4 cycloalkyl and p=0 2 for Cyc being C.sub.3 cycloalkyl; Y is O, S, or NR, where R.dbd.H, alkyl or aryl; X is O, S, NR, or CR.sup.3R.sup.4; Z is H, alkyl, cycloalkyl, aryl or (cyclo)alkylcarbonyl; R.sup.1 is H, alkyl, aryl or O; R.sup.2 is H, alkyl or aryl; R.sup.3 and R.sup.4 are, independently, H, alkyl or aryl; and n is an integer from 1 to 10; or a pharmaceutically acceptable salt, ester or prodrug thereof.

 
Web www.patentalert.com

< Tooth cleaning powders and methods of use thereof

< Apparatus for displaying drawings

> Benzotriazol-1-yl-aminoacetonitrile compounds and their use in the control of parasite disease

> Device and method for examining a body lumen

~ 00279