A Compound of formula ##STR00001## (wherein X is O or S and R.sup.1
R.sup.5 are disclosed herein) or a pharmaceutically acceptable salt
thereof (each being a "Piperazine Compound"), pharmaceutical compositions
comprising a Piperazine Compound and methods for treating or preventing
pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease,
parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition,
psychosis, a cognitive disorder, a memory deficit, restricted brain
function, Huntington's chorea, amyotrophic lateral sclerosis, dementia,
retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or
depression in an animal comprising administering to an animal in need
thereof an effective amount of a Piperazine Compound are disclosed.