The present invention makes available an optimal concentration of a hedgehog polypeptide for modulating growth and/or cartilage production by chondrocytes. The present invention allows for improvements in the culturing of chondrocytes to develop cartilaginous tissue ex vivo suitable for implantation to replace damaged or deteriorated cartilage in a patient.

 
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< Drug delivery system

< Apparatus for providing electromagnetic biostimulation of tissue using optics and echo imaging

> Prevascularized constructs for implantation to provide blood perfusion

> Microfabrication of membranes containing projections and grooves for growing cells

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