The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity.

 
Web www.patentalert.com

< Drosophila tumor necrosis factor class molecule polynucleotides and variants thereof

< Regulation of gene expression through manipulation of mRNA splicing and its uses

> TNF-inducible promoters and methods for using

> Tumor necrosis factor receptor-5

~ 00269