The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function mutations.

 
Web www.patentalert.com

< Sugar and lipid metabolism regulators in plants IV

< Texaphyrin coordination compounds and uses thereof

> 9-Ketospinosyn derivatives

> Antisense design

~ 00269