An active noise control system is capable of canceling out noise in the passenger compartment of a vehicle based on low-frequency road noise. The active noise control system has a feed-forward control unit for being supplied with reference signals highly correlated to noise from a noise source and generating a noise cancellation signal which is out of phase to noise in the passenger compartment of the vehicle, and a canceling sound generating unit disposed in the passenger compartment for generating a noise canceling sound in response to the noise cancellation signal from said feed-forward control unit. The active noise control system also has microphones for generating reference signals which are positioned respectively near the base of the front seat, near the center of a roof, and within a trunk compartment, i.e., respectively at vibrational antinodes of a primary or secondary acoustic normal mode of the passenger compartment in the longitudinal direction thereof. Output signals from the microphones are supplied as the reference signals.