Embodiments of the present invention relate to systems and methods for blocking delivery of an electronic communication. In an embodiment, a method includes receiving at least a portion of a first electronic communication that includes a first electronic communication source address and a first electronic communication recipient address. User electronic communication blocking profile data is accessed, in which the user electronic communication blocking profile data includes a plurality of user electronic communication blocking records. Each user electronic communication blocking record of at least a subset of the plurality of user electronic communication blocking records includes a recipient identifier field to store a recipient identifier and a sender identifier field to store a sender identifier. A first user electronic communication blocking record is selected based at least in part on the first electronic communication source address and the first electronic communication recipient address. Delivery of the first electronic communication to the first electronic communication recipient address is blocked based at least in part on the selected first user electronic communication blocking record.