The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.

 
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> Methods and compositions utilizing an alternative splice variant of the sigma-1 receptor

> Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions

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