A drug delivery system for administering preset doses of a substance such as a drug, vaccine or the like. The drug delivery system includes a holder and a pre-filled drug container such as a syringe which is retained in the holder. The drug container includes a barrel for containing the substance, a movable stopper situated within the barrel, and a blunt end having an opening through which the substance within the barrel can be expelled. The holder includes a distal portion and a proximal portion, each configured to accommodate the drug container, with the distal portion being able to be assembled to the proximal portion, which acts as a plunger rod during activation of the delivery system. A plurality of slots are provided on the holder that permit multiple equal doses of the substance to be administered to each nostril of the patient.