The invention features a novel gene encoding methionine synthase reductase. The
invention also features a method for detecting an increased likelihood of hyperhomocysteinemia
and, in turn, an increased or decreased likelihood of neural tube defects, cardiovascular
disease, or cancer. The invention also features therapeutic methods for treating
and/or reducing the risk of cardiovascular disease, cancer, or neural tube defects.
Also provided are the sequences of the human methionine synthase reductase gene
and protein and compounds and kits for performing the methods of the invention.