The present invention provides recombinant respiratory syncytial viruses (RSV) in which all of the surface glycoprotein genes encoding the attachment protein G, the fusion protein F, and the Small Hydrophobic protein SH are deleted. The genes are replaced by a chimeric gene encoding a heterologous entry protein derived from the Vesicular Stomatitis Virus G protein or GP64 of baculovirus. Alternatively, the replacement proteins are provided in trans. Marker genes such as those encoding -glucuronidase (GUS) and green fluorescent protein (EGFP) are also added to the upstream and downstream side of the hybrid gene for easy detection. These infectious recombinant respiratory syncytial viruses offer alternatives and improvements as vaccine candidates.

 
Web www.patentalert.com

< Expression modulating sequences

< Starch branching enzymes

> Chlamydia trachomatis polynucleotides and vectors, recombinant host cells, DNA chips or kits containing the same

> Transdiffentiation of transfected epidermal basal cells into neural progenitor cells, neuronal cells and/or glial cells

~ 00261