Methods and compositions containing bicifadine are provided for the
treatment and prevention of hyperthermia in mammalian subjects. The
methods and compositions may be used to prevent or treat fever, pyresis,
menopausal hot flashes; peri menopausal hot flashes, postmenopausal hot
flashes, hot flashes caused by anti-estrogen therapy, hot flashes
secondary to surgical removal of estrogen producing tissue, hot flashes
caused by radiation therapy, malignant hyperthermia, serotonin syndrome,
heat stroke, febrile seizures, and neuroleptic malignant syndrome, among
other conditions. Additional compositions and methods are provided
employing bicifadine to treat pyresis and simultaneously elicit an
analgesic response in mammalian subjects. Yet additional compositions and
methods are provided which employ bicifadine in combination with a second
antipyretic agent, a second analgesic agent, or a different therapeutic
agent to yield more effective antipyretic treatment tools, and/or dual
activity therapeutic methods and formulations useful to prevent or reduce
hyperthermia and one or more additional symptoms (e.g., pain, or
depression) in mammalian subjects.