Disclosed are the novel compounds as growth hormone secretagogues represented
by structural Formula (I), wherein R1 is, substituted or unsubstituted
alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkoxy,
substituted or unsubstituted aryl, or substituted or unsubstituted amino, X is
—CO— or —SO2—, Y is Formula (II), wherein n
is an integer from 0-4, R4 is hydrogen, substituted or unsubstituted
alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl,
R5 and R6 are independently selected from hydrogen, substituted
or unsubstituted alkyl, or R5 and R6 or R4 and
R5 are taken together to form substituted or unsubstituted alkylene,
R2 is hydrogen, or substituted or unsubstituted alkyl, R3 is
substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted
or unsubstituted aryl, D is substituted or unsubstituted amino, substituted or
unsubstituted alkoxy, or substituted or unsubstituted alkylthio, * represents an
asymmetric center, and pharmaceutically acceptable salts and individual isomers
thereof, which have growth hormone releasing activity in humans or animals.