The present invention aims to provide cyclic peptide derivatives having motilin receptor antagonist activity and are useful as pharmaceuticals. The present invention provides compounds of general formula (1): ##STR1##

wherein R₁ represents an optionally substituted phenyl group or the like; R₂ represents an amino group or the like; R₃ to R₆ represent a hydrogen atom, a methyl group or the like; R₇ represents a hydrogen atom or the like; V to Z represent a carbonyl group or a methylene group; m represents an integer of 0-2; and n represents an integer of 0-3; or a hydrate or a pharmaceutically acceptable salt thereof.