The present invention relates to analogs of estradiol, which, in their most preferred
embodiment, act as locally active estrogens without significant systemic action.
A series of 15-estradiol ester compounds is presented which exhibit excellent
biological activity for use in pharmaceutical compositions for the treatment of
symptomology associated with menopause. The present invention is therefore directed
to compounds according to the structure:
##STR1##
where X is
##STR2##
R is H, a C1 to C5 alkyl group, optionally substituted
with at least one halogen group, such as CH2CH2F, or other
group (e.g., CH2CHF2, CH2CF3 or CF3
group); and
m is from 0-5, preferably from 0-2.
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