The present disclosure relates to a single step method for purifying PAI-1, PAI-1 fragments and PAI-1 mutants using a metal chelate resin. The disclosure further relates to the purified PAI-1 obtained by the disclosed method and uses for the purified PAI-1.

 
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> Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade
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