The present invention relates to a lectin protein prepared from Korean marine crab Philyra pisum, process for preparing the same and the use thereof. This protein can be used as a diagnosing agent or a carrier protein that chemically binds to various anti-cancer drugs owing to its capability that specifically recognizes N-glycolylneuraminic acid, and, in addition, used as an anti-cancer drug in view of its anti-proliferation effect.