The present invention is directed to novel methods for assaying for modulators
of GADD45 polypeptide activity. The invention also provides means to sensitize
a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors
of GADD45 polypeptide activity. The invention further provides polypeptides which
interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the
G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode
such polypeptides.
