Methods are provided for preparing internucleotide phosphorothioate linkages that are enriched in the Sp or Rp enantiomer comprising coupling a synthon with a 2'-substituted nucleoside in the presence of coupling agent that is selected to enhance either the Rp or Spenantiomer according to its pKa.

 
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> DUAL-FUNCTIONAL ION EXCHANGE RESINS FROM AGRICULTURAL BY-PRODUCTS

> Process for the preparation of cellulose derivatives containing amino groups
~ 00240