A guitar pickup switching system for a three pickup guitar has a bridge pickup, a middle pickup, and a neck pickup for an electric guitar. This invention utilizes a switch arrangement which permits the three pickup guitar player to select outputs of the pickups in any one of 29 series, parallel, in-phase, and/or out-of-phase combinations. A guitar pickup switching system for a two pickup guitar has a bridge pickup and a neck pickup for an electric guitar. This invention utilizes a switch arrangement which permits the two pickup guitar player to select outputs of the pickups in any one of 6 series, parallel, in-phase, and/or out-of-phase combinations.