New intracorporeal radiodense medicaments and certain medical uses and methods
for use of such high energy phototherapeutic medicaments for treatment of human
or animal tissue are described, wherein a primary active component of such medicaments
is a halogenated xanthene or halogenated xanthene derivative. The halogenated xanthenes
constitute a family of potent radiosensitizers that become photoactivated upon
irradiation of the treatment site with ionizing radiation. In embodiments of the
present invention, such medicaments are used for treatment of a variety of conditions
affecting the skin and related organs, the mouth and digestive tract and related
organs, the urinary and reproductive tracts and related organs, the respiratory
tract and related organs, the circulatory system and related organs, the head and
neck, the endocrine and lymphoreticular systems and related organs, various other
tissues, such as connective tissues and various tissue surfaces exposed during
surgery, as well as various tissues exhibiting microbial or parasitic infection.
In another embodiment, such medicaments are produced in various formulations including
liquid, semisolid, solid or aerosol delivery vehicles.