Sulfonylamino phenylacetamide derivatives of the general formula
##STR1##
are disclosed. Pharmaceutical compositions containing the compounds and methods
for their use are also disclosed. In certain embodiments, the compounds of the
invention that, preferably:
(1) bind with high affinity to opioid receptors;
(2) display good opioid receptor selectivity of versus and
versus ; and
(3) do not substantially inhibit cytochrome P450 enzymatic activity, in
particular CYP2D6, CYP2C9 and CYP3A4.
