The present invention encompasses compounds of Formula (I) and pharmaceutically acceptable salts or hydrates thereof. The compounds are inhibitors of granzyme B and are useful for treating autoimmune and chronic inflammatory diseases. Pharmaceutical compositions and methods of use are also included.

 
Web www.patentalert.com

< RNA interference mediated inhibition of stromal cell-derived factor-1 (SDF-1) gene expression using short interfering nucleic acid (siNA)

< Tricyclic-heteroaryl compounds useful as kinase inhibitors

> Method for treating nervous system disorders and conditions

> Novel piperidyl derivatives of quinazoline and isoquinoline

~ 00234