The present invention provides a process for making an in vivo model of human leukemia. The process includes the steps of: pre-conditioning an immunodeficient rodent by administering to the rodent a sub-lethal dose of irradiation and injecting the rodent with an effective pre-conditioning amount of human fetal cord blood mononuclear cells; maintaining the rodent for from about 5 to 10 days; and injecting the rodent with an effective engrafting amount of primary human leukemia cells. An in vivo and in vitro model of human leukemia are also provided.


< Proteins involved in the regulation of energy homeostasis

< Screening assays and methods of tumor treatment

> GPR54 knock-out mammals and screening methods using them

> Transgenic non-human animals for producing chimeric antibodies

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