The present invention relates to processes for converting clarithromycin Form
I to clarithromycin Form II, which include slurrying clarithromycin the Form I
in water. The present invention also relates to processes for the preparation of
clarithromycin Form II by converting erythromycin A to clarithromycin and thereafter
converting clarithromycin Form I to clarithromycin Form II by slurrying.