Mucin peptide epitopes are inserted into the coat protein of a plant virus
(e.g., a comovirus such as CPMV) having a beta-barrel structure at an immunogenically
effective site, such as in a loop connecting beta sheets or at/near the C-terminus.
The resulting chimaeric virus particles are extremely immunogenic, giving better
results than KLH conjugation and not requiring the addition of exogenous adjuvant.
They are effective at mucosal surfaces, particularly when administered intranasally.