The present invention relates generally to mill blank constructions to facilitate the manufacture of dental restorations. A given mill blank is formed in a shape (i.e. with a given geometry) that has been predetermined to reduce material waste when the mill blank is machined into the final part. A set of two or more blanks each having such characteristics comprise a smart blank "library." In one embodiment, a smart blank library includes a sufficient number of unique blanks such that, when the geometry of the designed restoration is known, the smart blank with a highest yield can be selected for use in milling the restoration. The "yield" of a given smart blank represents the amount of material of the smart blank that is actually used in the final restoration. Automated processes for smart blank inventory management and smart blank selection are also described.