Compounds of Formula (I):
##STR1##
wherein Ar1 is aryl; Ar2 is hydrogen, cycloalkyl, aryl
or heteroaryl; Z is —C(O) or a single bond; R1, R2,
R3, R4 and R5 are independently hydrogen or alkyl
optionally substituted with hydroxy; alk is an alkylene chain of one to six carbon
atoms; X is —O—, —NRh (where Rh is hydrogen
or alkyl), (CR6R7)m(where R6 and R7
are independently in each occurrence hydrogen or alkyl and m is an integer
from 0 to 3), or —S(O)n (wherein n is an integer from 0 to 2);
or prodrugs thereof, and pharmaceutically acceptable salts thereof,
are inhibitors of CCR3 useful for treating eosinophil induced diseases such as asthma.
