The invention pertains to synthetic (s) peptides derived from the viral regulatory
protein R (Vpr) of the human immunodeficiency virus type 1 (HIV-1), particularly
the chemical synthesis of the 96 amino acid full length Vpr protein (sVpr1-96),
of a 47 amino acid long N-terminal (sVpr1-47), of a 49 amino acid long
C-terminal fragment (sVpr48-96) as well as fragments thereof (sVpr1-20
and sVpr21-40) and further approximately 15 amino acid long fragments
of sVpr1-96. As fragments or full length products of the HIV-1 regulatory
protein, those products are used in biological assays, for molecular and structural
characterization of Vpr and domains thereof, as well as for the development of
anti-Vpr antibodies directed against Vpr peptide sequences.
