Safety eyewear (10) having interchangeable lens(es) (28,30) is provided. To provide for interchange of the lenses (28,30) in the frame (12), upper and lower frame members (32,34) are molded from a harder, more rigid plastic while lateral temple portions (20,22), and a central nose bridge portion (18) are molded from a softer, more elastic material. The entire frame structure (12) is preferably molded as a unitary piece to form a unitary frame having rigid upper and lower frame portions (32,34) joined by flexible intermediate portions (18,20,22). In this regard, the upper and lower frame portions (32,34) can be flexed or stretched relative to each other to temporarily separate the frame portions (32,34) and open up the lens openings (24,26).